T. Parish

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor

The paper examines the bactericidal activity of NITD-349, an MmpL3 inhibitor, showing inoculum-dependent kill kinetics and enhanced efficacy when combined with isoniazid.

Identification of 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis

The paper identifies 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis, showing improved potency and reduced cytotoxicity but poor metabolic stability.

Rv0233 is not essential for the survival of Mycobacterium tuberculosis in stress conditions

This study shows that Rv0233 is not essential for M. tuberculosis survival under various stress conditions or in macrophages.

Chemical exploration of a highly selective scaffold with activity against intracellular Mycobacterium tuberculosis

The paper identifies thiourea derivatives with high potency against intracellular Mycobacterium tuberculosis and good selectivity over eukaryotic cells.

Triazolopyrimidines target aerobic respiration in Mycobacterium tuberculosis

This study identifies triazolopyrimidines as inhibitors of Mycobacterium tuberculosis cytochrome bc1 complex, showing resistance linked to QcrB mutations and efficacy against intracellular bacteria.

Identification of novel chemical scaffolds that inhibit the growth of Mycobacterium tuberculosis in macrophages

This study identifies five chemical classes that inhibit intracellular Mycobacterium tuberculosis growth in macrophages, with some also active against extracellular bacteria.

A novel benzoxaborole works by targeting FabI in Escherichia coli

This study identifies a benzoxaborole compound that targets FabI in E. coli, showing resistance mutations occur in FabI and dependence on NAD+ for activity.

InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis

The paper tests two diazaborine molecules against non-replicating Mycobacterium tuberculosis and finds they reduce viability by >3 logs in 21 days.

Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis

The study investigates whether phenoxyalkylimidazole compounds are subject to efflux in Mycobacterium tuberculosis, finding that analogs with an oxadiazole moiety show improved potency with efflux inhibitors.

A rapid method to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis at low pH

The paper develops a method to assess compound activity against non-replicating Mycobacterium tuberculosis at low pH, finding that some compounds are effective while others are not.

Phenylhydrazones are active against non-replicating Mycobacterium tuberculosis

This study shows that phenylhydrazones are active against non-replicating Mycobacterium tuberculosis, with some compounds showing enhanced activity under hypoxic conditions.

A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis

The paper develops a high-throughput whole-cell screen to identify inhibitors of Mycobacterium tuberculosis growth, identifying three chemical classes with ≥90% growth inhibition.

Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

The paper shows that cell wall inhibitors enhance rifampicin accumulation in Mycobacterium tuberculosis by increasing cellular permeability, suggesting potential for improved tuberculosis treatment combinations.

Activation of 2,4-diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a putative dioxygenase

The paper shows that Rv3161c in M. tuberculosis metabolizes diaminoquinazolines, as evidenced by the presence of the parent compound in a mutant strain and a mono-hydroxylated metabolite in the wild-type.

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.