Force-dependent activation of actin elongation factor mDia1 protects the cytoskeleton from mechanical damage and facilitates stress fiber repair.
F. R. Valencia, E. Sandoval, J. Liu, S. V. Plotnikov
The paper shows that mDia1-mediated actin polymerization at focal adhesions reduces tension on stress fibers, preventing mechanical damage and enabling repair.
bioRxiv · Feb 8, 2021Cell Biology