A novel combination of Class-I fumarases and metabolites (α-ketoglutarate and fumarate) signal the DNA damage response in E. coli.
Y. Silas, E. Singer, N. Lehming, O. Pines
This paper shows that in E. coli, Class-I fumarases participate in DNA damage repair through a novel signaling mechanism involving alpha-ketoglutarate and the enzyme AlkB.
bioRxiv · Aug 4, 2020 · PreprintMicrobiology