Dual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation
E. Stadnicki, H. Ludewig, R. P. Kumar, X. Wang, Y. Qiao, D. Kern, N. Bradshaw
The paper identifies dual-action kinase inhibitors that block the active site and enhance p38α dephosphorylation by stabilizing an accessible activation loop conformation.
bioRxiv · May 15, 2024 · PreprintBiochemistry