Y. Qiao

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

In silico MS/MS prediction for peptidoglycan profiling uncovers novel anti-inflammatory peptidoglycan fragments of the gut microbiota

This paper develops a computational tool to predict peptidoglycan MS/MS spectra, enabling automated profiling of gut microbiota-derived PGNs and identifying anti-inflammatory anhydro-PGNs in Bifidobacterium.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies

This paper develops humanized mouse models of metastatic prostate cancer to evaluate therapies, showing improved immune interactions and response to hormonal and immunotherapies.

Plant selection and ecological microhabitat drive domestications of shrub-associated microbiomes in a revegetated shrub ecosystem

This study examines how plant selection and ecological microhabitats influence the microbiomes of revegetated shrubs, finding that microhabitats, not plant species, primarily drive microbial community composition.

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

This study identifies Calponin 2's role in kidney fibrosis by linking cellular mechanics to metabolic reprogramming via fatty acid oxidation regulation.

Streptomyces alleviate abiotic stress in plant by producing pteridic acids

This study identifies pteridic acids produced by Streptomyces that alleviate drought and salinity stress in Arabidopsis by promoting root growth and inducing stress response genes.

An armored marine reptile from the Early Triassic of South China

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

A warmer growing season triggers earlier following spring phenology

The paper shows warmer temperatures during the previous growing season advance spring phenology in the Northern Hemisphere, with a decline in this effect over time.

TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila

This study identifies TOR signalling as critical for lipid metabolic remodelling and survival in Drosophila during enteric infection.

MPI8 is Potent Against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L

The paper evaluates MPro inhibitors for SARS-CoV-2, finding MPI8 selectively inhibits both MPro and host cathepsin L, enhancing antiviral efficacy with reduced toxicity.

Cellular Activities of SARS-CoV-2 Main Protease Inhibitors Reveal Their Unique Characteristics

This paper evaluates the cellular potency of SARS-CoV-2 MPro inhibitors using a fluorescent flow cytometry assay, revealing that most inhibitors have weak cellular activity despite strong antiviral effects.

Drug Repurposing for the SARS-CoV-2 Papain-Like Protease

This study screens inhibitors against SARS-CoV-2 PLpro, identifying several potent compounds with IC50 values below 60 μM, including SJB2-043 with an IC50 of 0.56 μM.

Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsies

This study uses rapid autopsy and whole genome sequencing to analyze metastatic evolution in a patient, identifying subclone incubators and four waves of metastatic expansion.

Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate-degrading Enzymes

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

OncoGEMINI: Software for Investigating Tumor Variants From Multiple Biopsies With Integrated Cancer Annotations

OncoGEMINI is a software tool that helps analyze tumor variants from multiple biopsies and integrates cancer annotations to identify mutations driving subclonal evolution.

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

A Novel Water-Soluble Photosensitizer for Photodynamic Inactivation of Gram-Positive Bacteria

This paper develops a novel water-soluble photosensitizer, sorbicillinoids, for antimicrobial photodynamic therapy that effectively inactivates Gram-positive bacteria under UV light without significant toxicity.

Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.