The Src and Abl family kinases activate the Spleen Tyrosine Kinase to maximize phagocytosis and Leishmania infection
I. Ullah, U. Barrie, R. M. Kernen, E. T. Mamula, F. T. H. Khuong, L. M. Booshehri, E. L. Rhodes, J. M. Bradford, A. Datta, D. M. Wetzel
This study shows that Src and Abl family kinases activate SYK to enhance Leishmania uptake by macrophages, leading to increased disease in mice.
bioRxiv · Nov 14, 2022 · PreprintMicrobiology