MAPK/ERK Activation in Macrophages Promotes Leishmania Internalization and Pathogenesis
U. Barrie, K. Floyd, A. Datta, D. M. Wetzel
This study shows that MAPK/ERK signaling in macrophages promotes Leishmania uptake and disease severity, with trametinib reducing infection in mice.
bioRxiv · Dec 8, 2022 · PreprintMicrobiology