Cigarette smoke induces pulmonary arterial dysfunction through an imbalance in the guanylyl cyclase redox status.
J. Sevilla-Montero, J. Pino-Fadon, O. Munar-Rubert, M. Villegas-Esguevillas, B. Climent, M. Agro, C. Choya-Foces, A. Martinez-Ruiz, E. Balsa, C. Munoz, R. M. Gomez-Punter, E. Vazquez-Espinosa, A. Cogolludo, M. J. Calzada
This study shows cigarette smoke extract impairs pulmonary artery function by disrupting mitochondrial redox balance and guanylyl cyclase activity, suggesting mitochondrial-targeted antioxidants could treat COPD-related pulmonary hypertension.
bioRxiv · Feb 21, 2022 · PreprintCell Biology