Cell BiologybioRxivPreprint
Cigarette smoke induces pulmonary arterial dysfunction through an imbalance in the guanylyl cyclase redox status.
J. Sevilla-Montero, J. Pino-Fadon, O. Munar-Rubert…·M. J. Calzada
This study shows cigarette smoke extract impairs pulmonary artery function by disrupting mitochondrial redox balance and guanylyl cyclase activity, suggesting mitochondrial-targeted antioxidants could treat COPD-related pulmonary hypertension.
DOI 10.1101/2022.02.21.481310