Author

E. Woerle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Grohmann· 2 shared A. Newman· 1 shared A. Schmidbauer· 1 shared G. Burgio· 1 shared G. Zinner· 1 shared L. Jakob· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

D. Grohmann

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2 papers

Recent·Most cited

Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain

E. Woerle, A. Newman, G. Burgio, D. Grohmann

This study investigates the role of helix 1 and the bridge helix in the allosteric activation of FnCas12a by showing their coordinated movement is essential for lid opening and DNA cleavage.

bioRxiv · Mar 15, 2022Biochemistry

Decoupling the bridge helix of Cas12a results in a reduced trimming activity and impaired conformational transitions

E. Woerle, L. Jakob, A. Schmidbauer, G. Zinner, D. Grohmann

This study shows that modifying the bridge helix of Cas12a reduces its trimming activity and affects its conformational changes.

bioRxiv · Feb 25, 2021Biochemistry