Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
B. Lee, S. J. Park, S. Lee, J. Lee, E. Lee, E.-S. Yoo, W.-S. Chung, J.-W. Sohn, B.-C. Oh, S. Kim
This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.
bioRxiv · Sep 27, 2021Cancer Biology