S. J. Park

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

CD20 is a mammalian odorant receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators

This study identifies CD20 as an odorant receptor in mice that mediates innate predator avoidance behavior by detecting predator-derived compounds.

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

Chromosome-level genome assembly of Euphorbia peplus, a model system for plant latex, reveals that relative lack of Ty3 transposons contributed to its small genome size

This paper presents a chromosome-level genome assembly of Euphorbia peplus, identifies a gene cluster for ingenol mebutate biosynthesis, and explains its small genome size through restricted Ty3 transposon expansion.

The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight

The paper identifies novel resistance genes in Solanum americanum against Phytophthora infestans by analyzing genome variation and effector recognition.

Three consecutive glycolysis enzymes are involved in autophagic flux regulation through monitoring nutrient availability

This study identifies three glycolysis enzymes (TPI, GAPC, PGK) that negatively regulate autophagy by monitoring nutrient availability through their interaction with ATG101.

Newly discovered alleles of the tomato antiflorigen gene SELF PRUNING provide a range of plant compactness and yield

The paper identifies new alleles of the tomato SELF PRUNING gene that alter plant compactness and yield, with sp-5732 increasing yield by up to 42%.

Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR

This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.

Intestinal epithelial IPMK protects mice from experimental colitis via governing colonic tuft cell development

This study shows that IPMK in intestinal epithelial cells protects against colitis by regulating tuft cell development and cholinergic signaling.

Computational metabolomics illuminates the lineage-specific diversification of resin glycoside acylsugars in the morning glory (Convolvulaceae) family

This study uses computational metabolomics to analyze resin glycoside diversity in morning glory species, revealing lineage-specific structural variations and biosynthetic pathway diversification.

Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

Inhibition of SARS-CoV-2 viral entry in vitro upon blocking N- and O-glycan elaboration

This study shows that blocking N- and O-glycan biosynthesis reduces SARS-CoV-2 viral entry by affecting Spike protein proteolysis and RBD presentation.

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden

This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.

Characterization of Sex Differences in Ocular HSV-1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild Type and Herpesvirus Entry Mediator Knockout Mice

This study investigates sex differences in ocular HSV-1 infection and Herpes Stromal Keratitis pathogenesis in wild type and HVEM knockout mice, finding no significant sex-based differences in disease outcomes.