Fragment Screening by Weak Affinity Chromatography Identifies Ligands for Neisseria gonorrhoeae Undecaprenyl Diphosphate Synthase
André da Silva Santiago, Bruno Sergio do Amaral, Edgar Llontopp, Priscila Zonzini Ramos, Lucas R. de Souza, Micael Rodrigues Cunha, Erika Piccirillo, Vitor M. Almeida, Ronaldo A. Pilli, Gabriela Barreiro, Katlin B. Massirer, Rafael M. Couñago
This study identifies ligands for Neisseria gonorrhoeae UPPS using weak affinity chromatography and crystallography, revealing binding sites and structural insights for drug development.
bioRxiv · May 21, 2025 · PreprintMicrobiology