Rafael M. Couñago

This study identifies KKT2 and CRK9 as essential kinases for Leishmania cell cycle progression using chemical genetics and CRISPR-Cas9.

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This study identifies ligands for Neisseria gonorrhoeae UPPS using weak affinity chromatography and crystallography, revealing binding sites and structural insights for drug development.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

This study presents six novel co-structures of CAMKK2 bound to small molecule ligands and shows some ligand binding is enthalpy driven.