Katlin B. Massirer

This study shows that BctCBA in B. pertussis binds citrate-chelated Zn2+ and Ni2+, revealing a novel metal acquisition mechanism.

The paper curates 222 genes associated with autism spectrum disorder (ASD) using the EAGLE framework, identifying 78 with definitive evidence and highlighting differential expression patterns between ASD and broader neurodevelopmental disorders.

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

This study identifies ligands for Neisseria gonorrhoeae UPPS using weak affinity chromatography and crystallography, revealing binding sites and structural insights for drug development.

This study characterizes NAT10 in Leishmania mexicana, showing its nuclear localization, essentiality, and role in parasite differentiation and metabolism.

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

The paper develops a yeast-based platform to identify Plasmodium vivax DHS inhibitors, finding two compounds that selectively inhibit parasite DHS over human DHS.

This study identifies UHMK1 as a splicing regulatory kinase by showing its role in phosphorylation, alternative splicing, and cellular processes through integrated phosphoproteomics and RNA-seq analyses.

This study presents six novel co-structures of CAMKK2 bound to small molecule ligands and shows some ligand binding is enthalpy driven.

BioFeatureFinder identifies distinguishing genomic features by analyzing biological landmarks using a combination of statistical tests and machine learning, showing reliability in large-scale datasets.