Reduced 4E-BP1 activity leads to acquired capivasertib resistance via increased cap-dependent protein synthesis.
Helen E. Grimsley, Jasmine Marie Jakubowski, Denis T. Akan, Edith Blackburn, Michelle Dawn Garrett
This study identifies reduced 4E-BP1 activity and increased cap-dependent protein synthesis as mechanisms of acquired resistance to the AKT inhibitor capivasertib in ovarian cancer.
bioRxiv · Oct 10, 2025 · PreprintCancer Biology