Helen E. Grimsley

The paper identifies the 9-1-1 complex as essential for stabilizing ssDNA gaps in BRCA2-deficient cells through an ATR-independent mechanism, highlighting its role in preventing pathological expansion and DNA damage.

This study identifies reduced 4E-BP1 activity and increased cap-dependent protein synthesis as mechanisms of acquired resistance to the AKT inhibitor capivasertib in ovarian cancer.

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

The paper shows that a single replication fork barrier activates a local ATR-dependent checkpoint response in human cells, leading to localized DNA damage signaling without affecting global replication.