Author
University of KentORCID 0000-0002-3939-1673Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Helen E. Grimsley, Jasmine Marie Jakubowski, Denis T. Akan…·Michelle Dawn Garrett
This study identifies reduced 4E-BP1 activity and increased cap-dependent protein synthesis as mechanisms of acquired resistance to the AKT inhibitor capivasertib in ovarian cancer.
Geraud N. Sansom, Emily P. Friar, David Shorthouse…·Christopher J. Serpell
This study identifies molecular pathways of madecassic acid's anti-liver cancer activity using chemical proteomics and RNAseq, showing its interactions with proteins related to metabolism and nucleic acid processing.
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme…·Martin Michaelis
This study characterizes phenotypic plasticity in EGFR inhibitor-resistant NSCLC cell lines, showing diverse resistance mechanisms and metabolic adaptations across sublines.
Trần Văn Chiến, Thao Thi Phuong Tran, Nguyễn Thế Anh…·Tran Van Sung
This study synthesizes and tests six silybin derivatives, finding one shows 12-fold stronger cytotoxicity against liver cancer cells than silybin itself.
Bini Claringbold, Steven Vance, Alexandra R. Paul…·Christopher J. Serpell
The paper develops sequence-defined oligophosphoesters to inhibit the KRAS G12D/RAF1 interaction, achieving low IC50 values and selectivity for the mutant form.