Metformin decreases RAN proteins, rescues splicing abnormalities and improves behavioral phenotypes in SCA8 BAC mice
Lisa E. L. Romano, Setsuki Tsukagoshi, Emily E Davey, Ramadan Ajredini, Kamat Manasi, Tala V.R. Ortiz, Eduardo Rijos, Nathan J. Bourgon, Elaine S Ames, Timothy J. Garrett, John D. Cleary, Eric T. Wang, Laura P.W. Ranum
Metformin reduces RAN proteins, improves splicing, and enhances behavioral and neuropathological outcomes in SCA8 BAC mice.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience