Author

Ramadan Ajredini

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

Laura P.W. RanumiD· 2 shared Alexis B. Tays· 1 shared Anthony T. YachnisiD· 1 shared Deborah Morrison· 1 shared Eduardo Rijos· 1 shared Elaine S Ames· 1 shared Emily E DaveyiD· 1 shared Eric T. WangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Laura P.W. RanumORCID

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2 papers

Recent·Most cited

Repeat associated non-AUG translation as a common mechanism for the polyGln ataxias

Mónica Báñez-Coronel, Tao Zu, Madeline Aldridge, Shu Guo, Ramadan Ajredini, Deborah Morrison, Alexis B. Tays, Lisa A. Duvick, Olga Pletniková, Anthony T. Yachnis, Juan Carlos Troncoso, Henry Lauris Paulson, Hayley S. McLoughlin, Tetsuo Ashizawa, S. H. Subramony, , Laura P.W. Ranum

The paper identifies sense and antisense RAN proteins as a common mechanism in CAG-SCAs, showing their accumulation and toxicity in brain regions and demonstrating metformin's ability to reduce RAN protein levels.

Cell Reports · Dec 19, 2025Peer-reviewedNeuroscience

Metformin decreases RAN proteins, rescues splicing abnormalities and improves behavioral phenotypes in SCA8 BAC mice

Lisa E. L. Romano, Setsuki Tsukagoshi, Emily E Davey, Ramadan Ajredini, Kamat Manasi, Tala V.R. Ortiz, Eduardo Rijos, Nathan J. Bourgon, Elaine S Ames, Timothy J. Garrett, John D. Cleary, Eric T. Wang, Laura P.W. Ranum

Metformin reduces RAN proteins, improves splicing, and enhances behavioral and neuropathological outcomes in SCA8 BAC mice.

bioRxiv · Aug 21, 2025 · PreprintNeuroscience