Timothy J. Garrett

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

The paper uses metabolomics to identify complex carbohydrate utilization in murine gut microbiota and develops a new medium to cultivate previously unculturable Firmicutes.

The paper shows that Galerina indica produces both psilocybin and amatoxins, revealing horizontal gene transfer of psilocybin biosynthesis.

This study identifies metabolomic changes in permethrin-resistant Anopheles gambiae mosquitoes from Cameroon, revealing metabolic and detoxification pathways contributing to resistance.

maxiM/Ze processes LC-HRMS metabolomics data using image recognition to automate feature detection, annotation, and alignment with minimal user input.

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

The paper develops a regression framework to analyze longitudinal metabolomics data and mental wellness in breast cancer patients, identifying metabolites associated with mental health changes over time.

This study compares XCMS and MZmine 2 for peak picking in untargeted metabolomics and finds significant discrepancies in biomarker identification across different sample types and parameters.

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

Metformin reduces RAN proteins, improves splicing, and enhances behavioral and neuropathological outcomes in SCA8 BAC mice.

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

The paper develops a matrix linear model to connect metabolite composition with individual characteristics, showing it can separate overlapping metabolite features.

The paper compares metabolomic profiles of diabetic and healthy dogs to identify similarities with human type 1 diabetes.