The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia
Kentson Lam, Yoon Joon Kim, Evelyn L. Tan, Carlo M. Ong, Andrea Zoey Liu, Fanny Zhou, Mary Jean Sunshine, Bernadette Anne Chua, Silvia Vicenzi, Katelyn Chen, Helena Yu, Pierce W. Ford, Jiehua Zhou, Yuning Hong, Eric J. Bennett, , Robert A. J. Signer
This study shows that proteasome inhibitors are ineffective in AML due to activation of HSF1 and autophagy, and that combining autophagy and proteasome inhibition effectively kills AML cells.
Blood · Oct 20, 2025Peer-reviewedCancer Biology