Silvia Vicenzi

This study shows that proteasome inhibitors are ineffective in AML due to activation of HSF1 and autophagy, and that combining autophagy and proteasome inhibition effectively kills AML cells.

This study identifies ELOVL2 as a key lipid metabolism enzyme that regulates B cell progenitor development and immune aging in mice and humans.

This study shows that Ryk signaling in astrocytes regulates scar formation and wound healing after spinal cord injury by coordinating cellular responses and inflammation resolution.

This paper develops and validates an optogenetic tool, PiGM-Iq, to inhibit Gq signaling and demonstrates its effects on behavior, axon guidance, and neuronal development in multiple organisms.

The paper uses a CRISPR/Cas9-based approach in zebrafish to identify genes affecting heart rate variability and confirms the role of known genes while highlighting a novel gene.