Robert A. J. Signer

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

The paper shows that inhibiting RhoA-mediated secretory autophagy in megakaryocytes reduces cytokine secretion and fibrosis in a mouse model of myelofibrosis.

The paper identifies distinct proteostasis programs in fetal, neonatal, and adult hematopoietic stem cells, showing how proteostasis changes during development and impacts stem cell function.

This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.

This study shows that proteasome inhibitors are ineffective in AML due to activation of HSF1 and autophagy, and that combining autophagy and proteasome inhibition effectively kills AML cells.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

This study shows that developmental stage-specific changes in protein synthesis rates make hematopoietic stem cells and erythroid progenitors differentially sensitive to ribosome biogenesis defects.