Proteostasis Remodeling Across Development Defines Fetal, Neonatal, and Adult Hematopoietic Stem Cell States
Helena Yu, Yoon Joon Kim, Katelyn Chen, Andrea Zoey Liu, Mary Jean Sunshine, Robert A. J. Signer
The paper identifies distinct proteostasis programs in fetal, neonatal, and adult hematopoietic stem cells, showing how proteostasis changes during development and impacts stem cell function.
bioRxiv · Dec 15, 2025 · PreprintDevelopmental Biology