Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking
Sara Linciano, Ylenia Mazzocato, Zhanna Romanyuk, Filippo Vascon, Lluc Farrera Soler, Edward Will, Yuyu Xing, Shiyu Chen, Yoichi Kumada, Marta Simeoni, Alessandro Scarso, Laura Cendron, Christian Heinis, Alessandro Angelini
This paper develops a yeast display method to screen macrocyclic peptide libraries, enabling better selection and affinity ranking of ligands against diverse protein targets.
Nature Communications · Jun 25, 2025Peer-reviewedBiochemistry