Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development
Sophie Wiszniak, Dimuthu Alankarage, Iman Lohraseb, Ceilidh L. Marchant, Genevieve A. Secker, Deepti Domingo, Jasmine Hartmann, Tianyang Zhang, Wendy Parker, John Toubia, Melissa A. White, Sandra Piltz, Markus Tondl, Eleni Giannoulatou, David Scott Winlaw, , Quenten Schwarz
The paper identifies DKK1 from neural crest cells as a regulator of Wnt signaling in the second heart field, crucial for cardiac outflow tract development and linked to congenital heart disease.
Nature Communications · Jan 22, 2026Peer-reviewedDevelopmental Biology