Author

Dimuthu Alankarage

Victor Chang Cardiac Research InstituteORCID 0000-0003-2056-2820Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Sally L. DunwoodieiD· 3 shared Richard Paul HarveyiD· 2 shared Alex J. McCanniD· 1 shared Alexander O. WardiD· 1 shared Ceilidh L. MarchantiD· 1 shared Chris MoraniD· 1 shared Congenital Heart Disease Synergy Group· 1 shared David Scott WinlawiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersDevelopmental Biology

Sally L. DunwoodieORCID

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3 papers

Recent·Most cited

Developmental BiologyNature CommunicationsPeer-reviewedJan 22, 2026

Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development

Sophie Wiszniak, Dimuthu Alankarage, Iman Lohraseb…·Quenten Schwarz

The paper identifies DKK1 from neural crest cells as a regulator of Wnt signaling in the second heart field, crucial for cardiac outflow tract development and linked to congenital heart disease.

4 citationstop 3%

mouseexperimental assay

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GenomicsbioRxivPreprintJun 20, 2025

NKX2-5 congenital heart disease mutations show diverse loss and gain of epigenomic, biochemical and chromatin search functions underpinning pathogenicity

Alexander O. Ward, Nicole Schönrock, Alex J. McCann…·Richard Paul Harvey

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.

DOI 10.1101/2025.06.20.659510

mouseChIP-seq

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GeneticseLifePeer-reviewedJun 5, 2023

Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

Mahdi Moradi Marjaneh, Edwin Philip Kirk, Ralph Patrick…·Richard Paul Harvey

This study identifies genetic and molecular factors underlying atrial septal defects in mice using QTL mapping and transcriptome analysis, revealing complex networks and non-coding variants involved.

6 citations

mousebulk RNA-seq

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