This study identifies TPD54 as a regulator of protein trafficking in melanoma, showing its role in disease progression and potential as a therapeutic target.

bioRxiv · May 12, 2026 · PreprintCancer Biology

Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development

Sophie Wiszniak, Dimuthu Alankarage, Iman Lohraseb, Ceilidh L. Marchant, Genevieve A. Secker, Deepti Domingo, Jasmine Hartmann, Tianyang Zhang, Wendy Parker, John Toubia, Melissa A. White, Sandra Piltz, Markus Tondl, Eleni Giannoulatou, David Scott Winlaw, , Quenten Schwarz

The paper identifies DKK1 from neural crest cells as a regulator of Wnt signaling in the second heart field, crucial for cardiac outflow tract development and linked to congenital heart disease.

Nature Communications · Jan 22, 2026Peer-reviewedDevelopmental Biology

Post-Transcriptional Control Of EMT Is Coordinated Through Combinatorial Targeting By Multiple microRNAs

Joseph Cursons, Katherine A. Pillman, Kaitlin G. Scheer, Philip A. Gregory, Momeneh Foroutan, Soroor Hediyeh-zadeh, John Toubia, Edmund J. Crampin, Gregory J. Goodall, Cameron P. Bracken, Melissa J. Davis

The paper shows that multiple microRNAs work together to control EMT by reducing noise and enhancing gene expression changes, more accurately reflecting endogenous regulation.

Cell Systems · Jul 1, 2018Peer-reviewedMolecular Biology