scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction
Justine Jia Wen Seow, Rhea Pai, Archita Mishra, Edwin Shepherdson, Tony Kiat Hon Lim, Brian K. P. Goh, Jerry Kok Yen Chan, Pierce K. H. Chow, Florent Ginhoux, Ramanuj DasGupta, Ankur Sharma
The paper uses scRNA-seq to identify TROP2+ liver progenitor cells co-expressing ACE2 and TMPRSS2, suggesting they may be targets for SARS-CoV-2 infection and contribute to COVID-19-associated liver dysfunction.
Frontiers in Medicine · Apr 22, 2021Peer-reviewedGenomics