Jerry Kok Yen Chan

Implementing Reproductive Carrier Screening to Include Diverse Asian Populations: Insights from Singapore

The paper describes the implementation of a reproductive carrier screening program in Singapore, focusing on diverse Asian populations and highlighting community engagement and initial outcomes.

Charting spatial ligand-target activity using Renoir

Renoir maps ligand-target activities across spatial topologies and identifies context-specific cell-cell interactions from spatial transcriptomics data.

Genetic liability to metabolic dysfunction modelled in early adulthood predicts cardiometabolic risk across the life course in Asian populations

This paper develops a polygenic score for metabolic syndrome in early adulthood and shows it predicts cardiometabolic risk across the life course in Asian populations.

Long-read transcriptome assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function

The paper uses long-read RNA-seq to create a comprehensive placental transcriptome reference, revealing high transcriptional complexity and identifying novel isoforms associated with metabolic and endocrine functions in gestational diabetes.

Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age

The paper shows PFAS affect birth weight and gestational age through distinct transcriptional network architectures, with network position, not fold-change, determining mediator importance.

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.

scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction

The paper uses scRNA-seq to identify TROP2+ liver progenitor cells co-expressing ACE2 and TMPRSS2, suggesting they may be targets for SARS-CoV-2 infection and contribute to COVID-19-associated liver dysfunction.