Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis
Aditya Misra, Efi M. Weitman, Michal Weitman, Jeannette R. Brook, Joseph M. Rone, Boryana Petrova, Randall Tyler Mertens, Narae Hwang, Katherin Zambrano Vera, Mark A. Perrella, Rebecca Marlene Baron, Naama Kanarek, Roni Nowarski
The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.
bioRxiv · May 22, 2025 · PreprintPathology