Jeannette R. Brook

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

This study optimizes LC-MS detection of retinoids in cerebrospinal fluid, showing that tailored parameters are needed for reliable identification in low-abundance biofluids.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.