Naama Kanarek

One-carbon metabolism sustains effector T cell function through cell-surface glycosylation

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

Optimization of Retinoid Detection in Cerebrospinal Fluid Using Liquid Chromatography Mass Spectrometry

This study optimizes LC-MS detection of retinoids in cerebrospinal fluid, showing that tailored parameters are needed for reliable identification in low-abundance biofluids.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis

The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance

This study identifies NDRG1 as a DNA repair protein that links pancreatic cancer stroma to chemoresistance by enhancing DNA damage repair through R-loop resolution.

Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

A scalable approach to absolute quantitation in metabolomics

This paper introduces Pyxis, a machine learning tool for absolute metabolite quantification in metabolomics, demonstrating its scalability and efficiency compared to traditional methods.

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.

Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid

The paper develops an optimized LC-MS method to measure thyroid hormones and metabolites in rodent CSF, revealing differences between pregnant and non-pregnant animals and across developmental stages.

Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation

This study uses metabolomics to analyze changes in mouse embryonic CSF after maternal immune activation, identifying elevated glucocorticoids and kynurenine pathway metabolites.

Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression

The paper identifies genes involved in mitochondrial and nuclear gene regulation for OXPHOS complex synthesis using genome-wide screens and characterizes their roles in mitochondrial RNA abundance and mitoribosome assembly.