Author

Mark A. Perrella

Brigham and Women's HospitalORCID 0000-0002-7219-7688Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aditya MisraiD· 1 shared Alan H. BeggsiD· 1 shared Behzad MoghadaszadehiD· 1 shared Boryana PetrovaiD· 1 shared Efi M. Weitman· 1 shared Jasmine LiniD· 1 shared Jeannette R. BrookiD· 1 shared Joseph M. RoneiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPathology

Aditya MisraORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis

Aditya Misra, Efi M. Weitman, Michal Weitman, Jeannette R. Brook, Joseph M. Rone, Boryana Petrova, Randall Tyler Mertens, Narae Hwang, Katherin Zambrano Vera, Mark A. Perrella, Rebecca Marlene Baron, Naama Kanarek, Roni Nowarski

The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.

bioRxiv · May 22, 2025 · PreprintPathology

Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex

Qifei Li, Jasmine Lin, Shiyu Luo, Klaus Schmitz‐Abe, Rohan Agrawal, Melissa Meng, Behzad Moghadaszadeh, Alan H. Beggs, Xiaoli Liu, Mark A. Perrella, Pankaj B. Agrawal

This paper investigates the role of SPEG in skeletal muscle biology using multi-omics approaches, revealing its interaction with the myospryn complex and its impact on mitochondrial function and calcium signaling.

bioRxiv · Apr 24, 2023 · PreprintMolecular Biology