Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation
Julian von Ehr, Lasse Oberstrass, Ege Yazgan, Lara I. Schnaubelt, Nicole Blümel, François McNicoll, Julia E. Weigand, Kathi Zarnack, Michaela Müller-McNicoll, Sophie Marianne Korn, Andreas Schlundt
This study defines Arid5a's DNA and RNA-binding preferences using biochemical and high-throughput methods, showing that disordered regions modulate its nucleic acid interactions and gene regulation.
Journal of Biological Chemistry · Jun 12, 2024Peer-reviewedBiochemistry