Lasse Oberstrass

This study determines the structure of the Roquin ZnF domain and shows it binds AU-rich elements, revealing how Roquin integrates RNA shape and sequence specificity through its ROQ-ZnF tandem.

This study defines Arid5a's DNA and RNA-binding preferences using biochemical and high-throughput methods, showing that disordered regions modulate its nucleic acid interactions and gene regulation.