Pui Y. Lee

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases

This study profiles B cell activation states using multi-omics data to identify genetic mechanisms underlying immune-mediated diseases.

Scoring gene importance by interpreting single-cell foundation models

The paper introduces SIGnature, a framework for scoring gene importance using attributions from scRNA-seq foundation models, and demonstrates its utility in identifying novel associations of the MS1 signature with hyperinflammatory conditions.

Multimodal Non-Invasive Biomarker Characterization of Structural and Functional Alterations in ADSS1 Myopathy

This study uses multimodal non-invasive assessments to characterize structural and functional alterations in ADSS1 myopathy, identifying biomarkers for disease monitoring.

Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus

This study shows clonal overlap between Tph and Tfh cells in SLE patients and mice, suggesting shared developmental pathways and potential implications for immunosuppressive treatment.

RIPK1 Biallelic Activating Variants lead to Autoinflammatory Disease Driven by T cell Death

This study identifies biallelic RIPK1 activating variants causing autoinflammatory disease through T cell death and cytokine amplification.