Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity
Eike-Benjamin Braune, Dirk Wienke, Anita Seshire, Timo Heinrich, Martin Haraldsson, Sonia Laı́n, Urban Lendahl
The paper identifies small molecule Notch inhibitors through a cell-based screening system and shows that DHODH inhibition reduces Notch signalling.
Scientific Reports · Jun 6, 2026Peer-reviewedCancer Biology