Urban Lendahl

The paper identifies small molecule Notch inhibitors through a cell-based screening system and shows that DHODH inhibition reduces Notch signalling.

The paper creates a molecular atlas of mouse liver cell types using single-cell RNA sequencing, revealing new insights into hepatic endothelial and mesenchymal cells and their responses to fibrosis.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

This study shows active immunotherapy reduces NOTCH3 deposition in brain capillaries of CADASIL mice, with no adverse effects on behavior or vascular cells.

The paper identifies sex differences in bleeding risk and explores non-invasive vascular analysis in Alagille syndrome using mouse models and retinography.

The paper introduces NEPTUNE, an in utero nanoinjection method to study gene function in mouse embryos, and shows that Sptbn2 silencing causes neural tube defects and embryo resorption.