Cancer BiologyScientific ReportsPeer-reviewed
Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity
Eike-Benjamin Braune, Dirk Wienke, Anita Seshire…·Urban Lendahl
The paper identifies small molecule Notch inhibitors through a cell-based screening system and shows that DHODH inhibition reduces Notch signalling.
DOI 10.1038/s41598-026-55679-3