Dysregulation of the engulfment pathway in the gut fuels Inflammatory Bowel Disease
Katherine Suarez, Eileen Lim, Sujay Singh, Matheus Pereira, Linda Petronella Joosen, Stella-Rita Ibeawuchi, Ying Dunkel, Yash Mittal, Samuel B. Ho, Ranajoy Chattopadhyay, Monica Guma, Brigid S. Boland, Parambir S. Dulai, William J. Sandborn, Pradipta Ghosh, Soumita Das
This study shows that ELMO1 dysregulation in the gut epithelium and macrophages contributes to IBD by promoting bacterial internalization and pro-inflammatory cytokine production.
bioRxiv · Mar 12, 2018 · PreprintCell Biology