William J. Sandborn

Pathogenic Bacteroides fragilis strains can emerge from gut-resident commensals

This study identifies genetic factors enabling Bacteroides fragilis to transition from commensal to pathogenic by analyzing 813 strains and their genomic diversity.

Pangenome comparison of Bacteroides fragilis genomospecies unveil genetic diversity and ecological insights

This study compares the pangenome of Bacteroides fragilis genomospecies to reveal genetic diversity and ecological roles, finding division I and II strains represent distinct species with different functional adaptations.

Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease

The paper uses BoNE to identify dual PPARα/γ agonism as a therapeutic strategy for IBD, validated in preclinical models and patient-derived cells.

Dysregulation of the engulfment pathway in the gut fuels Inflammatory Bowel Disease

This study shows that ELMO1 dysregulation in the gut epithelium and macrophages contributes to IBD by promoting bacterial internalization and pro-inflammatory cytokine production.