Soumita Das

The paper investigates the druggability of the ELMO1/DOCK2 complex and introduces tools for analyzing protein interaction and MD trajectories.

This study identifies a link between ELMO1 and mitochondrial pathways in macrophages during Salmonella infection through proteome profiling and functional analysis.

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

This study shows that e-cigarette vaping increases adenoma formation in a mouse model of colorectal cancer, with dual exposure to e-cigarettes and cigarettes leading to greater tumorigenesis.

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

The paper identifies a 338-gene signature of macrophage reactivity and tolerance that predicts disease outcomes across diverse conditions and species.

The paper uses BoNE to identify dual PPARα/γ agonism as a therapeutic strategy for IBD, validated in preclinical models and patient-derived cells.

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.

This study shows that ELMO1 dysregulation in the gut epithelium and macrophages contributes to IBD by promoting bacterial internalization and pro-inflammatory cytokine production.