Natural microbial exposure imposes layered constraints on epithelial and type 2 immunity
Dovran Ovezgeldiyev, Rory Doolan, Vanessa Trefzer, Alina Baltensperger, Shirin Rezaei, Alexander Serra, Christina Pohl, Namitha Putananickal, Betina Chalethu, Elad kuku, Julian Dommann, Pierre Schneeberger, Solveig Runge, Vanessa Lang, Christina Gmeiner, , Tiffany Bouchery
The study shows that natural microbial exposure reduces tuft cell responsiveness in mice, affecting type 2 immunity and helminth resistance compared to sterile conditions.
bioRxiv · May 7, 2026 · PreprintImmunology