Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity.
Dovran Ovezgeldiyev, Vanessa Trefzer, Rory Doolan…·Tiffany Bouchery
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Swiss Tropical and Public Health InstituteORCID 0000-0003-3743-7356Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Dovran Ovezgeldiyev, Vanessa Trefzer, Rory Doolan…·Tiffany Bouchery
Dovran Ovezgeldiyev, Rory Doolan, Vanessa Trefzer…·Tiffany Bouchery
The study shows that natural microbial exposure reduces tuft cell responsiveness in mice, affecting type 2 immunity and helminth resistance compared to sterile conditions.
Dovran Ovezgeldiyev, Rory Doolan, Vanessa Trefzer…·Tiffany Bouchery
This study screens compounds from the MMV Pathogen Box against a rodent hookworm model to identify anti-blood-feeding agents, finding five compounds effective in vitro and well-tolerated in vivo.