Cell BiologyFree Radical Biology and MedicinePeer-reviewed
Lysosomal function, resistance to stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant
Elena Hernández-Gerez, Nuria Goya‐Iglesias, Álvaro Viedma-Poyatos…·Dolores Pérez‐Sala
This study shows that expressing the GFAP R239C mutant in astrocytes disrupts lysosomal function, acidification, and repair, contributing to proteostasis defects and neurodegeneration in Alexander disease.
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