An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseases.
Louis Papageorgiou, Eleni Mangana, Eleni Papakonstantinou, Io Diakou, Katerina Pierouli, Konstantina Dragoumani, Flora Bacopoulou, George Panagiotis Chrousos, Themis P. Exarchos, Panagiotis Vlamos, Elias Eliopoulos, Dimitriοs Vlachakis
This study identifies conserved motifs in TBK1 as potential pharmacological targets for treating Amyotrophic Lateral Sclerosis through evolutionary, structural, and mutational analysis.
Advances in experimental medicine and biology · Jan 1, 2023Peer-reviewedBioinformatics