George Panagiotis Chrousos

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

Role of lncRNAs related to NRs in the regulation of gene expression

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseases.

This study identifies conserved motifs in TBK1 as potential pharmacological targets for treating Amyotrophic Lateral Sclerosis through evolutionary, structural, and mutational analysis.

Semantic and population analysis of the genetic targets related to COVID-19 and its association with genes and diseases

The paper analyzes genetic targets related to COVID-19 using semantic methods and integrates population data to explore host genetic variation's role in disease.

A genomic study of the Japanese population focusing on the glucocorticoid receptor interactome highlights distinct genetic characteristics associated with stress response

The paper identifies population-specific SNPs in the glucocorticoid receptor interactome in Japanese individuals, highlighting potential roles in stress-related diseases.

ADRA2B and HTR1A: An updated study of the biogenic amine receptors reveals novel conserved motifs which play key role in Mental Disorders.

This study investigates conserved motifs in ADRA2B and HTR1A, two biogenic amine receptors, to understand their role in mental disorders through evolutionary and structural analysis.

DRDs and Brain Derived Neurotrophic Factor share a common therapeutic ground: A novel bioinformatic approach sheds new light towards pharmacological treatment of Cognitive and Behavioral Disorders.

The paper identifies genetic factors associated with cognitive and behavioral disorders using bioinformatics tools and develops regulatory networks for dopamine receptors and BDNF.

Alzheimer disease and Apolipoprotein E4: meningeal brain lymphatics point to new clues in pathogenesis

The paper investigates the role of meningeal lymphatic vessels in Alzheimer's disease, linking APO E4 to lymphatic dysfunction and amyloid-beta accumulation.