Dimitriοs Vlachakis

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

The paper investigates immune cell senescence in melanoma patients and finds that non-responders to immunotherapy have higher senescence in immune cells compared to responders.

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

This study uses computational methods to design novel anti-Ebola agents targeting the virus polymerase.

This study identifies conserved motifs in TBK1 as potential pharmacological targets for treating Amyotrophic Lateral Sclerosis through evolutionary, structural, and mutational analysis.

The paper analyzes genetic targets related to COVID-19 using semantic methods and integrates population data to explore host genetic variation's role in disease.

The paper identifies population-specific SNPs in the glucocorticoid receptor interactome in Japanese individuals, highlighting potential roles in stress-related diseases.

This study investigates conserved motifs in ADRA2B and HTR1A, two biogenic amine receptors, to understand their role in mental disorders through evolutionary and structural analysis.

The paper identifies genetic factors associated with cognitive and behavioral disorders using bioinformatics tools and develops regulatory networks for dopamine receptors and BDNF.